The ROTRF supports important and innovative projects in basic and clinical research applicable to the understanding and care of human organ transplant recipients and related tissue transplants, such as islet transplantation.
The ROTRF gives priority to projects focusing on understanding the pathogenesis and prevention of human transplantation diseases, including organ injury and rejection, viral infection, and late graft deterioration. Furthermore, the ROTRF may consider funding research that addresses related clinical issues in non-transplant patients, including hepatitis C infection and inflammatory processes relevant to human organ transplantation. The ROTRF also considers supporting research in new emerging technologies, such as genomics, proteomics and metabolomics, examining the pathogenesis of human disease states in organ transplantation. When animal models are used, the priority will be higher if they simulate the usual human counterpart, e.g MHC plus non-MHC incompatibilities developing typical lesions seen in human transplants.
|