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Dr. Karl Lemström
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Research Group
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Dr. Karl Lemström, Principal Investigator |
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MD. Erkki Kallio, Co-Investigator |
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Dr. Petri Koskinen, Co-Investigator |
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MD. Jussi Tikkanen, Co-Investigator |
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MD. Antti Nykänen, Research Associate |
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MB. Mikko Keränen, Research Associate |
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MB. Sandelin Henrik, Research Associate |
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MSc. Rainer Krebs, Research Associate |
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Location
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Helsinki University Hospital, Helsinki, Finland |
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Title
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Role of Hypoxia-Inducible Factor-1 in Cardiac Allograft Vasculopathy |
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Cardiac transplantation is a standard therapy for many end-stage heart diseases and returns patients to normal life. Although the short-term survival of heart transplant recipients has improved, there is a steady decline in graft function over time. Ischemia is an integral part in solid organ transplantation and is associated with impaired long-term graft survival. The recent discovery of transcription factor hypoxia inducible factor-1 (HIF-1) has unfolded a molecular link between hypoxia and regulation of a variety of genes involved in cellular adaptation to hypoxia. We aim to investigate the role of HIF-1 in cardiac allografts using experimental, pharmacological, gene vector and transgene-based strategies.
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(C) 2008, ROTRF, All rights reserved |
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