- Dr Karl Lemström, Principal Investigator
- Dr Petri Koskinen, Co-Investigator
- Dr Antti Nykänen, Research Associate
- Mr Mikko Keränen, Research Associate
- Mr Henrik Sandelin, Research Associate
- Mr Raimo Tuuminen, Research Associate
- Dr Jussi Tikkanen, Research Associate
- Mr Rainer Krebs, Research Associate
- University of Helsinki, Helsinki, Finland
- Role of Hypoxia Inducible Factor-1 in Cardiac Allograft Vasculopathy
Cardiac transplantation is a standard therapy for many end-stage heart diseases and returns patients to normal life. Although the short-term survival of heart transplant recipients has improved, there is a steady decline in graft function over time. Ischemia is an integral part in solid organ transplantation and is associated with impaired long-term graft survival. The recent discovery of transcription factor hypoxia inducible factor-1 (HIF-1) has unfolded a molecular link between hypoxia and regulation of a variety of genes involved in cellular adaptation to hypoxia.
We aim to investigate the role of HIF-1 in cardiac allografts using experimental, pharmacological, gene vector and transgene-based strategies.