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The ROTRF supported important and innovative projects in clinical research applicable to the understanding and care of human organ transplant recipients and related tissue transplants, such as islet transplantation.

The ROTRF gave priority to clinically oriented research projects, such as observational clinical studies, or studies that use human transplant samples for laboratory examinations, and focused on understanding the pathogenesis and prevention of human transplantation diseases, including organ injury and rejection, viral infection, and late graft deterioration. Furthermore, the ROTRF considered funding research that addresses related clinical issues in non-transplant patients, including hepatitis C infection and other viral infections, and inflammatory processes relevant to human organ transplantation. These related clinical issues had to demonstrate their relevance to disease phenotypes in organ transplant patients. The Trustees also considered funding studies that investigate transplant populations, ethics, organ preservation and allocation, and healthcare delivery. Moreover, the ROTRF welcomed research in new emerging technologies that examine the pathogenesis of human disease states in organ transplantation. If animal models were used to complement the clinical research, a higher priority was given to those that simulate pathological states and mechanisms operating in human organ transplantation.

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