Research Group
- Prof. Irving Kron, Principal Investigator
- Prof. Victor Laubach, Co-Investigator
- A. Prof. Christine Lau, Co-Investigator
- Prof. Mark Stoler, Collaborator
- A. Prof. Robert Figler, Collaborator
- Dr Daniel Mulloy, Research Associate
- Dr Matthew Stone, Research Associate
- Mr Anthony Herring, Laboratory Manager
- Mrs Cynthia Dodson, Laboratory Specialist
- Mrs Sheila Hammond, Laboratory Specialist
Location
- University of Virginia, Charlottesville, USA
Title
- Improving Lung Transplantation Outcomes with Novel Reperfusion Methods
Outcomes for lung transplantation remain the poorest of any solid organ transplant. The principal mechanism for primary graft failure is ischemia-reperfusion injury (IRI). IRI is the direct result of cold ice storage of the donor lung, which results in significant donor lung injury upon recipient reimplantation and warm blood perfusion. Ex vivo lung perfusion (EVLP) is a method of donor lung perfusion, preservation, and IRI prevention. This technique provides a rehabilitation strategy for non-heart-beating donation and donor pool expansion. This study will define the optimal strategy for EVLP combined with a novel adenosine therapy to prevent lung IRI while potentially supporting donor pool expansion with non-heart-beating donation.
Final Report
